WHAT IS DYSPORT®?

About DYSPORT®

Wrinkles aren’t your style and the “frozen look” isn’t either. For adults who want a natural look, there’s Dysport, a prescription injection proven to help smooth the appearance of moderate to severe frown lines between the eyebrows without changing the look or movement of the rest of your face. Untreated muscles still work normally, so you can continue to express feelings naturally. It’s the lines that are minimized, not your expressions.

And because Dysport delivers the natural-looking results people want, 97% of users say they’d do it again.1*†‡ Additionally, Dysport is approved in 69 countries2 and has 25 years of clinical experience worldwide. Find out more about Dysportbelow, including how it works and what you need to know before starting treatment.

*Subject’s satisfaction and self-perception reported 3 weeks after treatment (n=531).
 Design: Multicenter, prospective, non-interventional observational study conducted in France, Germany, Spain and the United Kingdom (n=533). Subjects were eligible if the investigator had decided to prescribe Dysport according to the labeling. Subjects completed questionnaires at 3 weeks and 4 months after treatment.
User = Clinical trial subject.
§Includes therapeutic and aesthetic uses

Learn More About Dysport

One injection. Five points.

Dysport treats moderate to severe frown lines between the eyebrows by reducing specific muscle activity. Wrinkles are caused by repeated movements and muscle contractions1, which means they can even develop in younger adults. One injection into each of 5 points between and above the eyebrows temporarily prevents muscle contractions that cause frown lines, leaving the rest of your face to move naturally. In other words, no frozen look, just natural-looking results. You can control your look instead of your look controlling you.

Cited from https://www.dysportusa.com/what-is-dysport

Forget frown lines between the eyebrows for up to 4 months.

You’ve got better things to do than think about what your frown lines look like. The majority of users see improvement in just 2–3 days after treatment.4-6 In just one 10- to 20-minute treatment, Dysport may help improve the look of your frown lines between the eyebrows for up to 4 months.4,5,7# Results of repeat treatments may be comparable to your first use. Another plus? There is minimal downtime after your treatment, which means you can get back to your day faster.

 

Users = clinical trial subjects

A secondary endpoint based on Kaplan-Meier estimates of cumulative rate of time to onset of response. The median time to onset of response was 3 days in GL-1 (Dysport 55/105 [52%], Placebo 3/53 [6%]) and GL-2 (Dysport 36/71 [51%], Placebo 9/71 [13%]), and 2 days in GL-3 (Dysport 110/200 [55%], Placebo 4/100 [4%]).4-6

#GL-1 and GL-3 evaluated subjects for at least 150 days following treatment. Based on investigator assessment, response was maintained for up to 4 months in both GL-1 (Dysport 24/105 [23%], Placebo 2/53 [4%]) and GL-3 (Dysport 58/200 [29%], Placebo 1/100 [1%]).4,5,7

Cited from https://www.dysportusa.com/what-is-dysport

 

Frown lines between your eyebrows got you down?

Stand up to those lines with Dysport. If you’re under 65 and seeking treatment to improve the look of wrinkles between your eyebrows, ask your specialist if Dysport is right for you. But before you begin, read below to help you make the safest, most informed decision.

References
  1. Molina B, Grangier Y, Mole B, et al. Patient satisfaction after the treatment of glabellar lines with Botulinum toxin type A (Speywood Unit): a multi-centre European observational study. J Eur Acad Dermatol Venereol. 2015;29(7):1382-8. doi:10.1111/djv.12881. Epub 2014 Dec 12.
  2. Data on file. Ipsen World-Wide Marketing Authorisation Status. Fort Worth, TX: Galderma Laboratories, L.P., February 2017.
  3. Medicines and Healthcare products Regulatory Agency (MHRA). Botulinum Toxin Type A Powder For Solution For Injection (Clostridium botulinum toxin type A – Haemagglutinin complex). http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con108644.pdf . Accessed May 11, 2015.
  4. Data on file. MA-Y-97-52120-719 (GL-1) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  5. Data on file. MA-Y-97-52120-718 (GL-3) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  6. Data on file. MA-Y-97-52120-085 (GL-2) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  7. Dysport for Injection Package Insert. Fort Worth, TX: Galderma Laboratories, L.P.; September 2017.

Cited from https://www.dysportusa.com/what-is-dysport

DO NOT TAKE DYSPORT IF YOU:

  • Are allergic to Dysport or any of the ingredients in Dysport. See the end of the Dysport Medication Guide for a list of ingredients in Dysport
  • Are allergic to cow’s milk protein
  • Had an allergic reaction to any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox®(onabotulinumtoxinA) or Xeomin® (incobotulinumtoxinA)
  • Have a skin infection at the planned injection site

DYSPORT MAY NOT BE RIGHT FOR YOU IF:

  • You have had surgical changes to your face
  • You have very weak muscles in the treatment area
  • Your face looks very different from side to side
  • The injection site is inflamed
  • You have droopy eyelids or sagging eyelid folds
  • You have deep facial scars
  • You have thick, oily skin
  • Your wrinkles can’t be smoothed by spreading them apart

The only way to know for sure if Dysport is right for you is to speak with your healthcare provider. Don’t have one? Find a specialist near you who administers Dysport.

See below for Dysport Important Safety Information, including Boxed Warning, and Medication Guide.

IMPORTANT SAFETY INFORMATION

Dysport is a prescription injection for temporary improvement in the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults less than 65 years of age.

Important Safety Information

What is the most important information you should know about Dysport?

Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect areas of the body away from the injection site. Symptoms can happen hours to weeks after injection and may include swallowing and breathing problems, loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there have been reports of death. You are at the highest risk if these problems are pre-existing before injection.

These effects could make it unsafe for you to drive a car, operate machinery, or do other dangerous activities.

Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®, have a skin infection at the planned injection site, under 18 years of age, or are pregnant or breastfeeding.

The dose of Dysport is not the same as the dose of any other botulinum toxin product and cannot be compared to the dose of any other product you may have used.

Tell your doctor about any swallowing or breathing difficulties and all your muscle or nerve conditions such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome, which may increase the risk of serious side effects including difficulty swallowing and difficulty breathing.

Tell your doctor about all of your medical conditions, including if you have surgical changes to your face, very weak muscles in the treatment area, any abnormal facial change, injection site inflammation, droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, wrinkles that can’t be smoothed by spreading them apart, or if you are pregnant or breastfeeding or planning to become pregnant or breastfeed.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause serious side effects. Do not start any new medicines while taking Dysport without talking to your doctor first.

Especially tell your doctor if you: have received any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA), or Xeomin® (incobotulinumtoxinA), in the last four months or any in the past (be sure your doctor knows exactly which product you received, have recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take a sleep medicine.

Common Side Effects

The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.

Ask your doctor if Dysport is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Dysport Full Prescribing Information including Medication Guide.

Cited from https://www.dysportusa.com/what-is-dysport

Aging & Wrinkles

Understand your skin

The more you know about your skin’s aging process, the better you’ll be able to keep it looking its best. Scroll down for helpful information and tips about between the brow frown lines and wrinkles so you and your healthcare provider can decide if Dysport is right for you.

Frown line facts:

Your skin care regimen probably includes a number of over-the-counter cosmetic products. That’s perfectly fine. But when it comes to improving the look of moderate to severe frown lines between the eyebrows, a prescription treatment may be the right choice for lasting results.

Of course time is a factor. But wrinkles and frown lines between the brows don’t simply mean you’re getting older. They’re caused by repeated movements and muscle contractions1, which means they can even develop in younger adults. Frown lines, “elevens” or glabellar lines are the product of repeated movement of corrugator supercilii, procerus and depressor supercilii muscles. It’s the mark of an expressive face. Dysport lets you keep the expressions and minimize the evidence.

You squint, you smile, you frown — wrinkles happen. That’s life. But that doesn’t mean you have to accept it. Dysport is here to help you stand up to the lines between your eyebrows and take control of your look.

Aging Tips

Avoid UV exposure.

Excessive exposure to ultraviolet rays is thought to be a major culprit for rapidly aging skin. Sun damages your skin and causes a loss of collagen, which can lead to drooping and wrinkles.2 If you’re the outdoorsy type, think sunblock and shade to help keep your skin as healthy and young-looking as possible.

Stay hydrated.

Drinking plenty of water will help prevent your skin from becoming overly dry.

Avoid processed foods and sugars.

When sugar comes in contact with collagen (a protein), a reaction called glycation occurs. Glycation can damage collagen, compromise the integrity and regeneration of skin tissue, and accelerate aging of the skin.5,6

Aging in men

Gentlemen, congratulations on making the bold choice to treat your frown lines between your eyebrows. The fact is, because your face moves when you frown, smile or squint, frown lines can still appear even if you use the best men’s skin care products. And, as a man, your expression lines tend to be deeper, so a prescription injection could be the treatment you need to get the natural look you want. Check out our gallery to see how Dysport can help improve the appearance of between-the-brow frown lines for men.

Aging in women

Work out. Eat right. Take care of your skin. Rinse. Repeat. It’s your every day. Everything you do in your daily routine can help you stay happy and healthy. But sometimes, for those inevitable things in life — like frown lines between the eyebrows — a step outside the routine may be in order. Everybody ages differently, but if you express yourself through movements in your face (like most people do), Dysport can help smooth those frown lines and get the natural look you want. See how Dysport works.

See below for Dysport Important Safety Information and Medication Guide.

References
  1. Molina B, Grangier Y, Mole B, et al. Ribe N. Patient satisfaction after the treatment of glabellar lines with Botulinum toxin type A (Speywood Unit): a multi-centre, prospective, non-interventional European observational study. J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1382-1388. doi:10.1111/jdv.12881. Epub 2014 Dec 12.
  2. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic Acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253-258.
  3. Vleggaar D, Fitzgerald R. Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7(3):209-220.
  4. Ganjoo A. 35A Aging Skin. In: Venkataram M, ed. ACS(I) Textbook on Cutaneous & Aesthetic Surgery. New Delhi: Jaypee Brothers Medical Publishers; 2012:545-549.
  5. Lyons TJ, Bailie KE, Dyer DG, Dunn JA, Baynes JW. Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus. J Clin Invest. 1991;87(6):1910-1915.
  6. Dandby FW. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010;28(4):409-411.

Cited from https://www.dysportusa.com/aging-and-wrinkles

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